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Registration Number

0213U007132, 0110U001189 , R & D reports

Title

Peculiarities of hormonal and metabolic disorders in aging patients with type 2 diabetes in dependence from insulinemia

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Head

Korpachev Vadim Valerievich, Доктор медичних наук

Registration Date

05-04-2013

Organization

State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine"

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Object of investigation: hormonal and metabolic state in aged type 2 diabetic (T2D) patients. Aim of investigation: to investigate peculiarities of hormonal and metabolic disturbances in aged T2D patients in dependence from the level of insulinemia and to substantiate pharmacotherapeutical approaches to treatment of patients with regard of these peculiarities. Methods: clinical, biochemical, hormonal, genetical, statistical. Results: it was revealed that in T2D patients, levels of gonadal and pituitarical androgens decrease in parallel with ageing and SHBG increase. Increase of saturated fatty acids and decrease of unsaturated fatty acids in T2M patients was shown. Rise of uric acid production was shown to be a useful marker of dismetabolic iron overload syndrome (DIOS). Interrelations between nucleotide repeats in androgen receptor gene and insulin supplying were examinated. Negative influences of decrease of serum insulin on the state of bones and joints, and on psycho-somatic depressing manifestations in T2M patients were revealed. The results allowed to develop a number of criterions for clinical and laboratory diagnostics and to formulate practical recommendations concerning of therapy of investigated disturbances in different stages of disease. This may contribute to increase of efficacy of treatment of different categories of patients.Degree of introduction: scientific article, reports, patent. Sphere of application: endocrinology.

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Гуріна Н.М.
Ковальчук А.В.
Корпачев В.В.
Корпачева Т.І.
Корпачева-Зінич Л.В.
Кушнарьова Н.М.
Лукашова Р.Г.
Мельниченко С.В.
Плашенкова В.О.
Ховака В.В.
Чубук Н.Г.
Шевченко Т.М.
Шупрович А.А.

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2020-04-02