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Registration Number

0214U005313, 0113U000198 , R & D reports

Title

Bioanalytical application of luminescent probes on the basis of the new lanthanide complexes

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Head

Antonovich V.P.,

Registration Date

20-01-2015

Organization

A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine

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Object of research - complexes of samarium and terbium with oxyquinoline carboxylic acid derivatives. The aim of research - to establish the quenching of luminescence of samarium (III) and terbium (III) in their complexes (donors) in the implementation of fluorescence resonance energy transfer (FRET) on squaraine dye K8-1642 and hemoglobin (acceptors). The optimal conditions of complex formation of terbium (III) and samarium (III) ions with oxyquinoline carboxylic acid derivatives (L1,2) and luminescent properties of these complexes have been established. The effect of quenching of luminescence of samarium (III) in complexes with L1,2 in the presence of the squaraine dye K8-1642 has been found. It has been proposed new pairs of donor - acceptor (complexes of samarium (III) with L1,2 - squaraine dye K8-1642) for the implementation of FRET. Forster radius and the overlap integrals of the fluorescence spectra of energy donor with the absorption spectrum of the dye K8-1642 have been calculated. Selective luminescence quenching of terbium ions (III) in complex with L1 by hemoglobin has been established and explained that electronic excitation energy transfer from the donor (Tb (III) -L1) to an acceptor (hemoglobin). By using fluorescent probe Tb (III) -L1 a highly sensitive, simple and rapid method of hemoglobin determination in blood samples has been developed. Field of application: bioanalytical chemistry, luminescent analysis.

Product Description

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І.І. Леоненко
А.В. Єгорова
В.П. Антонович
Г.В. Федосенко
К.О.Вітюкова
Н.П. Єфрюшина
О.І. Теслюк
Ю.В.Скрипинець

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2020-04-02