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Registration Number

0215U003378, 0110U005959 , R & D reports

Title

Clusters of silver from a few atoms: synthesis, stabilizing and application in fluorescent biotechnology.

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Head

Demchenko Alexander P., Доктор біологічних наук

Registration Date

28-01-2015

Organization

A.V.Palladin Institute of Biochemistry of National Academy of Sciences

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Obtained nanocomposites of organic dyes (tioflavin T) and silver nanoclusters and studied their interaction with the cell membrane and fluorescently labeled cellular components. Investigated the possibility of creating fluorescent nanohybrids with desired properties from available nanocomposites and polymers, biopolymers and proteins. Detected the conditions and developed a protocol to obtain nanohybrids and found their fluorescent properties. Established nanohybrids of silver with tioflavinom in T 2-propanol, which have absorption spectrum of 330-340 nm for visualization the structures of cells HeLa. It is shown that they specifically stained nuclear structure stable when working on confocal microscopy and can be recommended for imaging in the study of living cells. Scientific and practical importance: The obtained nanocomposites with bifunctional properties may find wide application, and above all, as a material for imaging in biological research and clinic.

Product Description

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Канюк Микола Ігоревич
Назаренко Володимир Іванович

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2020-04-02