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Information × Registration Number 0221U106822, 0121U110599 , R & D reports Title Development of multifunctional biocompatible nanocontainers and nanocarriers for delivery, diagnosis and treatment popup.stage_title Head Yefimova Svitlana L., Доктор фізико-математичних наук Registration Date 21-12-2021 Organization Institute for scintillation materials NAS Ukraine popup.description2 During the implementation of the research project developed methods for obtaining hydrosols based on nanocrystals of oxides of rare earth elements Re1-xEuxVO4 (Re = Y, Gd, La) and CeO2-x method of complex homogenization, which allows to obtain hydrosols with a given particle dispersion and eliminates the possibility of toxic the results of biochemical research in the future. The kinetic and thermodynamic stability of nanoparticle/organic molecule complexes has been studied. It is established that complexes based on inorganic nanoparticles are inert highly stable systems at room and physiological temperatures. A laboratory method for obtaining water-soluble powders of hydrophobic organic substances (drugs) in the form of inclusion complexes with cyclodextrins has been developed. Powders containing included mefenamic acid (MFA) in a complex with 2-hydroxypropyl-β-cyclodextrin (MFA/HP-β-CD) and melatonin in a complex with randomly methylated β-cyclodextrin (MT/RMβCD) have been obtained. The stoichiometry of the complex, stability constants and thermodynamic parameters of the complex formation has been calculated. Powders containing included vitamin K1 in a complex with 2-hydroxypropyl-β-cyclodextrin has been obtained. It was found that the developed vitamin K1 complexes in combination with ascorbic acid show an effective antitumor effect, inhibiting the proliferation of mouse sarcoma cells L929. Product Description popup.authors Yefimova Svitlana L. Borovyi Ihor A. Grygorova Ganna V. Kavok Natalia S. Klochkov Volodymyr K. popup.nrat_date 2021-12-21 Close