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Information × Registration Number 0223U000506, 0120U102510 , R & D reports Title To optimize the diagnosis and to develop methods for non-specific prevention of community-acquired pneumonia caused by coronaviruses or their combination with bacterial pathogens popup.stage_title Head Dziublyk Oleksandr Ya., Доктор медичних наук Registration Date 09-01-2023 Organization State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine" popup.description2 The object of the study – 100 patients with community-acquired pneumonia(CAP) caused by coronaviruses, strains of viruses and bacteria.The aim of the work is to improve the etiological and clinical-radiological diagnosis and methods of non-specific prevention of CAP caused by coronaviruses or their combination with bacterial pathogens. Methods – clinical and radiological, microbiological, statistical.It was established that decamethoxine demonstrates clearly expressed virulicidal activity in vitro against the model strain coronavirus IBV, and its cytotoxic effect depends on the type of cell culture. An interaction of decamethoxine with the active center of the main protease (Mpro) of IBV was proved and a high degree of structural similarity between Mpro in IBV and SARS-CoV-2 was revealed. It was established that aminocaproic acid showes in vitro low toxicity and antiviral activity.The algorithm for etiologic diagnostic of CAP caused by coronaviruses or their combination with bacterials includes a complex of clinical-instrumental and laboratory studies, the scope of which is determined by the severity of the CAP course, by the existence and nature of complications. The scheme of microbiological identification of the main causative agents of CAP includes modern diagnostic rapid tests(RT) in combination with molecular biological and classical bacteriological diagnosis. This scheme makes it possible to establish the etiological pathogen in 89,0% of patients in a short period of time (10-15min) and to prescribe etiotropic therapy in time. It was proven the possibility of using digital processing of thorax CT images of patients with COVID-19 by using the U-Net neural network.A method of non-specific prevention of CAP has been developed, and to prevent COVID-19 in contact persons, by using the decamethoxine. The method makes it to prevent development of coronavirus disease in 86.7% of contact persons and prevent infection of others. Sphere of application–pulmonology. Product Description popup.authors Bororova Olena L Velychko Olga O Gumenyuk Mykola Ivanovych Denysova Olha V Jublik Irina V. Dziublik Oleksandr Y Kapitan Heorhiy B Lynnyk Mykola I Mukhin Oleksandr O Sukhin Rostyslav Ye Trochymenko Olena P Yudina Liudmyla Volodymyrivna Yakovenko Oleg Kostyantynovych Iachnyk Vitalii A popup.nrat_date 2023-01-09 Close