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Registration Number

0223U003543, 0120U102042 , R & D reports

Title

To develop a strategy for the prevention and treatment of liver toxicity in patients with multidrug-resistant tuberculosis in chemotherapy and smoking

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Head

Butov Dmytro O., Доктор медичних наук

Registration Date

23-05-2023

Organization

Kharkiv National Medical University

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 The pathogenetic features developed by innovative and effective technologies for the treatment of toxic liver damage under the influence of antituberculosis therapy in patients with multidrug-resistant pulmonary tuberculosis were studied by studying biochemical and immunological parameters, mechanisms of interaction of macro- and microorganisms, resistance of pathogens to antituberculosis drugs, detection of mutations in the main resistance genes of Mycobacterium tuberculosis complex. A new method of sputum induction with a hypertonic solution was developed, which improves the quality of collected samples for microbiological detection of mycobacterium tuberculosis in sputum. It was found that in resistant forms of pulmonary tuberculosis, the tuberculous process in the organ is radiologically more widespread with the presence of a greater number of cavities and their larger size against the background of a more pronounced clinical picture and identification of tuberculosis mycobacteria than in sensitive tuberculosis.

Product Description

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Borysova O. L.
Butov Dmytro O.
Butova Tetiana Sergіyivna
Mysoedov Valery Vasilevich
Rudova Nataliia H
Sapelnyk N. M.
Solodjankin Oleksij S.

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2023-05-23