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Registration Number

0223U005815, 0122U000443 , R & D reports

Title

Development of new approaches to the synthesis of fluorine-containing polyfunctionalized natural compounds and their structural analogues

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Head

Ihor I. Herus, д.х.н.

Registration Date

31-12-2023

Organization

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

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The aim of the work is the design and development of methods for the synthesis of new 1,3-substituted di-/tri-fluoromethylated cyclobutanes as promising building blocks. The practical significance of the obtained results lies in the development of a practical method of obtaining new 1,3-substituted di-/tri-fluoromethylated cyclobutanes, promising building blocks for the synthesis of fluorinated potentially biologically active compounds. We summarized and systematized literature data on the synthesis of fluorinated analogs of biologically active compounds. A new general and simple method for obtaining 1,3-substituted di-/tri-fluoromethylated cyclobutanes, which are promising starting compounds for the synthesis of fluorinated potentially biologically active compounds, has been developed.

Product Description

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Ahunovych Volodymyr A.
Vdovenko Sergiy I.
Dolovanyuk Violetta G.
Klipkov Аnton А.
Kulik Irіna B.
Logvinenko Ivan G.
Rybakova Antonina V.
Romanenko Vladyslav D.
Ruchko Evgenia V.
Tarasenko Karen V.
Fedorenko Оlena А.
Feskov Іlia О.
Hilchevskiy Oleksandr М.
Shaitanova Olena M.

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2023-12-31