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Registration Number

0224U031465, 0123U101955 , R & D reports

Title

Molecular mechanisms of physical processes that determine the use of hydrogels in military medical technologies

Head

Bulavin Leonid А., Доктор фізико-математичних наук

Registration Date

30-04-2024

Organization

Taras Shevchenko National University of Kyiv

Description

 The work is aimed at creating the physical foundations of the latest military medical technologies based on various hydrogel systems, which will significantly improve the quality of the use of drugs in emergency medicine and offer fundamentally new solutions for creating more reliable and cheap nanocomposite hydrogels for paramedical applications. The object of research is the physical processes that occur in hydrogels when using hydrogels for wound treatment. The purpose of the work is to determine the molecular mechanisms of these processes. Using the turbometric method, the process of gel formation (sol-gel transition) in aqueous solutions of cellulose derivatives with impurities of ions was investigated. A theoretical model describing the kinetics of this process is proposed and a method for determining the surface tension coefficient of hydrogels is created. It is shown that the introduction of ions into the hydrogel affects the surface tension. The molecular mechanism responsible for such an effect has been determined. A molecular model of the hydrogel surface structure is proposed. The process of light reflection from the hydrogel surface was experimentally investigated. The parameters of the surface structure of the hydrogel were calculated. According to the comparative analysis of temperature, baric and chemical potential dependences of thermodynamic coefficients for water in the liquid state, it is shown that for water there is a special temperature of 420,20С, at which anomalous properties of water in the liquid state are revealed. Using the methods of small-angle X-ray and neutron scattering, the sol-gel transition in model systems of aqueous suspensions of nanodiamonds was investigated. Two stages of this process were identified, corresponding to the formation of structural levels with different compactness of aggregates. The molecular mechanism responsible for adsorption on the surface of the hydrogel has been theoretically established.

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Bardyk Vitalii Yu.
Zabashta Yurii F.
Kovalchuk Valerii I.
Kuzovkov Yurii Н.
Lebovka Mykola I.
Ohorodnyk Kateryna О.
Rudnikov Yevhenii Н.