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Information × Registration Number 0210U000979, 0107U002391 , R & D reports Title The study of fibrinolysis mechanism at the normal state, acute phase and oxidative stress conditions as a base for new plasminogen-containing class of thrombolytic drugs production popup.stage_title Head Kudinov Stanislav Olexandrovych, Registration Date 26-04-2010 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Patients with stable angina pectoris and chronic cardiac failure appeared to have hyperplasminogenemia and abnormal tissue plasminogen activator to inhibitor of plasminogen activator-1 (t-PA/PAІ-1) physiological ratio at 5 to 10 times increase of C-reactive protein level as inflammation marker. Original mechanism of hemostatic balance disorder during increasing of inflammation significantly caused by protein C deficiency was proposed. Preliminary data were received argumentative of the redox regulator elements are involved in PAI-1 secretion and in thrombin-dependent platelets activation. Considerable amount of extrinsic thiol groups in structure of plasminogen preparation proves disruption of some native disulphide bonds as elements of the secretory proteins' conformation stability. The proatherogenic role of SH-groups in some plasma protein structure was concluded to be probable. Product Description popup.authors Євстратова Ірина Нікіфорівна Діордієва Світлана Вікторівна Дроботько Тетяна Федорівна Корніліна Олена Михайлівна Паталах Ірина Іванівна Рока-Мойяна Марійовна Рясненко Людмила Петрівна Таланов Сергій Олександрович Урвант Леся Петрівна Харченко Світлана Михайлівна popup.nrat_date 2020-04-02 Close