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Registration Number

0218U002251, 0115U000364 , R & D reports

Title

"Develop an an algorithm for applying the complex modern radiological methods in the diagnosis of varions forms of treatment, accompanied be coronary artery disease".

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Head

Dykan Iryna,

Registration Date

06-02-2018

Organization

Diagnostic centre АMS of Ukraine "The health of elderly people"

Description

Object of the study: Magnetic resonance imaging (MRI), multidetector computed tomography (MCT) and echocardiography (EchoCG). A total of 62 patients aged 36 to 69 years were examined, of which 30 patients who underwent an acute myocardial infarction (MI) and who were treated for various postinfarction periods in a specialized institution - NNS "Institute of Cardiology named after academician SC Strazhesko" Ukraine, as well as examination in the State Institution "Institute of Nuclear Medicine and Radiology Diagnostics of the National Academy of Medical Sciences of Ukraine." The control group consisted of 32 people with verified coronary heart disease without myocardial infarction. Objective: to develop objective criteria for the effectiveness of treatment of patients with various forms of Coronary dasease and evaluation of structural and functional changes in myocardium of the left ventricle with the use of modern radiation research methods: cardio-MRI, MCT-ventriculography, echocardiography. Methods of investigation: magnetic resonance imaging (MRI), multidetector computed tomography (MCT) and echocardiography (EchoCG). It was established that according to cardio-MRI data, 10 (42%) patients showed signs of AMI and 14 (58%) patients with signs of late postinfarction changes in LV myocardium. During postinfarction period (3-120 months), scar changes (signs of cardiosclerosis) of LV myocardium were detected in all 14 patients (58%), of them 3 (21%) had an aneurysmal enlargement of the LV apex. In the group of patients with AMI in the amount of 10 people, microvascular obstruction (MVO) was found in the zone of ischemic lesion of the myocardium of the left ventricle - in 7 (70%), parietal thrombus of the upper limb in 2 (20%). In 1 patient (10%) of this group, intramyocardial hemorrhage was detected. Conclusions: In patients with different forms of IHD, in addition to the standard Echo-CG study, it is necessary to additionally carry out a complex cardio-MRI study, or MCT-ventriculography with functional analysis. At the same time, a complex cardio-MRI study allows in patients with MI not only to accurately determine the localization of postinfarction changes in the heart muscle and to assess the depth of ischemic lesion, as well as to reveal violations of segmental and global contractility of the myocardium for determining further treatment tactics and predicting the prognosis of the course of the disease.

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Дикан І.М.
Кравчук Є.Ю.
Феьків С.В.