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Registration Number

0221U101457, 0117U004977 , R & D reports

Title

To assess the impact of disfunctional adipose tissue on tumor microenvironment as well metastatic potential in overweight patients with gastro-intestinal cancers

Head

Ganusevych Iryna I., Доктор біологічних наук

Registration Date

21-01-2021

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Description

 It was shown, for the first time, that mitochondria of adipose tissue acquire an altered redox state under the influence of a tumor in overweight patients with gastrointestinal tract cancer. Indicators of redox state are associated with tumor factors of the microenvironment: an increase of tumor-associated adipocytes as an important source of energy for tumor progression, high levels of lactate/pyruvate ratio, and superoxide-generating activity of neutrophils in the blood, which reflect the hypoxic state and redox imbalance of the body. It was found that defects in the oxidative phosphorylation mechanism, deepening hypoxia, an increase of the superoxide radicals rate generation, the matrix metalloproteinases activity and DNA guanine oxidation in adjacent adipose tissue are associated to an aggressive phenotype, distant tumor metastasis and are promising markers for a personalized prognosis of gastrointestinal cancer. The use of these markers will increase the effectiveness of anticancer therapy and improve patient survival.

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Bubnovskaya Larysa M.
Burlaka Anatoliy P.
Virko Sergij V.
Verbinenko Alla V.
Vyskirko Sergii I.
Vovk Anastasiya V.
Galieieva Anastasiia M.
Ganusevych Iryna I.
Samoylenko Olena A.
Chernobai Vitalii A.
Shlyakhovenko Volodymyr Olejsijovych