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Registration Number

0222U004618, 0120U002197 , R & D reports

Title

Development of new curative and preventive means and pathogenetic substantiation of their usage in inflammatory periodontal diseases on the background of metabolic syndrome.

Head

Kravchenko Ludmila , к.б.н.

Registration Date

21-09-2022

Organization

Odessa National Medical University

Description

 The efficacy of the treatment – and – prophylactic complex, which includes the drug “Capillaroprotect”, used per os, in combination with local therapy of periodontal tissues with a new dental elixir based on propolis and biologically active substances of plant origin adaptogens with ultaphonophoresis was determined in experiment on 48 white male Wistar rats, aged 2-3 months. Under induced metabolic syndrome in rats, the use of the treatment-and-prophylactic complex newtralized the negative effects of the components of the pathological condition in the form of improved metabolism with normalization of glucose, triglycerides, cholesterol, anti-inflammatory interleukins level in the blood serum, improved liver condition and periodontal tissues. The treatment-and prophylactic complex on the background of MS simulation rendered a periodontal-protective effect and had positive influence on systems of antioxidant defence and nonspecific resistance both at the systemic level and in the periodontal tissues.

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Ivanova Yana I.
Ivchenko Natalia A.
Appelhans Olena L.
Bas Oleksiy A.
Kravchenko Lyudmila S
Polyakov Anatoly Ye