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Registration Number

0224U002970, 0123U100712 , R & D reports

Title

To determine the histological and immunohistochemical features of the growth and spread of non-small cell lung cancer to clarify histogenesis.

Head

Bolhova Lidiia S., Доктор медичних наук

Registration Date

19-03-2024

Organization

National Cancer Institute

Description

The object of the study: patients with squamous cell lung cancer (SCLC) - macroscopic and histological data. The goal of scientific research is to determine the histological features of the growth and spread of squamous cell lung cancer in order to clarify histogenesis. Research material and methods. The main clinical and macroscopic data of operative materials and histological studies of 15 patients with squamous cell lung cancer were studied. Histological preparations were prepared according to generally accepted methods and stained with hematoxylin and eosin. Olympus BX41, Olympus CX41 microscopes were used at magnifications: x200; x400; x1000. The histological type of neoplasm was established according to the International histological classification [17]. Research results. The age, sex of patients, number of tumor nodes on the surgical specimen, spread of RL, exophytic growth, damage to lymph nodes (LV) in 15 patients with RL and determined features of histological growth relative to the wall of the bronchus and lung parenchyma were determined. Main conclusions. Histological studies revealed the growth of PRL in the alveoli of all 15 patients in the direction from the basement membrane to their center, where necrosis develops, which confirms the generally recognized characteristic morphogenesis of epithelial (cancerous) tumors. On serial sections, the transition of the basal epithelium of the bronchus into the alveolus, in which the cancerous tumor is growing, is determined, which brings our research closer to determining the source of the development of PRL. To confirm the identified features, additional immunohistochemical studies are needed, which are planned to be performed at the next stage of the NDR implementation.

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Med Vladyslav V.