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Registration Number

0224U003126, 0121U113839 , R & D reports

Title

Medical sorbents and nanomaterials in experimental therapy of systemic manifestations of cytostatic disease (2.2.5.446)

Head

Sarnatskaya Veronika V., Доктор біологічних наук

Registration Date

10-04-2024

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Description

 A working fraction of granular highly active carbon sorbent from carbonitrate of nitrogen-containing resin VP-1AP with a bulk density of 0.073 g/cm3, sorption pore volume Vs = 5.29 cm3/g and an extremely large specific surface area of 4490 m2/g was obtained. A powder fraction with a homogeneous size distribution in the submicron range was obtained using a carbon sorbent mill. In aqueous suspension, the hydrodynamic diameters of the particles ranged from 0.35 to 4.9 μm with a mean value of 1.13 μm. The obtained fractions of granular sorbent and powder had a strong sorption potential according to the developed marker scale. It has been shown that daily administration of granular highly active carbon enterosorbent at a dose of 190 mg or twice weekly intraperitoneal injection of carbon particle suspension at a concentration of 1.4 mg/ml to rats with Guérin's carcinoma can reduce side effects of doxorubicin injection at a dose of 3. 25 mg/kg. It led to inhibition of tumour growth, formation of significant areas of fibrous tissue, reduction in the intensity of general toxic and inflammatory-dystrophic processes, manifestations of heart, liver and kidney dysfunction. Normalised the balance in the redox system, had a unidirectional positive corrective effect on the morphological and functional state of the studied organs, partially restored blood parameters and activated regenerative processes in the bone marrow. It was shown that, unlike carbon particles, carbon enterosorbents improved haematopoiesis, which may be due to certain differences in their physicochemical properties and methods of administration. The possibility of reducing the intensity of side effects from the administration of doxorubicin to rats with Guerin's carcinoma through the combined use of carbon enterosorbents and systemic administration of micro- and nanomaterials was confirmed.

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Bardakhivs'ka Kvitoslava I.
Herashchenko Bohdan I.
Klymchuk Dmytro O
Korneeva Liudmyla M.
Korotych Valentyna H.
Nikolaiev Volodymyr Н.
Paziuk Liubov M.
Sydorenko Oleksii S.
Snezhkova Elizaveta O.