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Registration Number

0224U031362, 0122U000770 , R & D reports

Title

Determination of osteoconductive and osteoinductive properties of polymer-hydroxyapatite biodegradable scaffolds

Head

Oleshko Oleksandr M., Кандидат медичних наук

Registration Date

16-04-2024

Organization

Sumy State University

Description

 In recent decades, biomaterials and polymers (HA, PLA and PCL,) have become a real alternative to traditional metals in orthopedics, surgery and cardiac surgery due to the possibility of complete elimination after performing its function. And the possibility of creating 3D-structures brings modern science to a completely different level. However, there are a number of disadvantages characteristic of metal structures, such as: uncontrolled resorption, discrepancy of mechanical properties (Young's modulus, etc.), as well as the lack of absolute biological neutrality of foreign material relative to bone tissue. These shortcomings are a major problem in the clinical use of degradable alloys, due to the likelihood of developing a number of clinical complications. Various methods are used to eliminate this problem: the creation of new alloys and post-cast processing, the formation of a protective coating or replacement of the metal base with hydroxyapatite, as well as the use of 3D printing technologies. This study is aimed at creating a completely new porous polycaprolactonehydroxyapatite scaffold obtained by 3D printing. The study will use different model concentrations and types of nanostructures of components to improve biocompatibility and antimicrobial properties, as well as determine the optimal process parameters (temperature, PCL/PLA ratio and metric parameters of pores and printing fibers). The terms of degradation and the dynamics of the release of elements, depending on the type, composition and structure of the scaffold, will also be studied. The biological response and the level of stimulation of osteogenesis will be assessed using commercially available cell lines: HOS-bone osteosarcoma, U2OS-human bone osteosarcoma, CHOhuCEACAM1-4L-Chinese hamster ovary cell, osteoblasts (selected from the periosteum)

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Hlushchenko Victoriia V.
Dryhval Bohdan O.
Dudko Yuliia S.
Lukianenko Maksym V.
Malysheva Tetiana V.
Oleshko Oleksandr M.
Oleshko Tetiana B.