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Registration Number

0224U031382, 0117U002465 , R & D reports

Title

The modern view on issues of diagnosis, prevention and forecasting of major dental diseases in young adults

Head

Biloklytska Halyna F., д.мед.н.

Registration Date

18-04-2024

Organization

Shupyk National Healthcare University of Ukraine

Description

 For the first time, the correlation has been revealed between smoking and the oral health status (r=0.499); additionally, an association has been found between the inflammatory activity (r=0.500) in periodontal tissues and an increase in the level of TNF-α in the oral fluid (r=0.419). This suggests that smoking plays a significant role in the development of periodontal diseases in young people. An increase in the frequency of mutant alleles of the TNF-a, the ACE (p<0.05; r=0.326) and eNOS (p<0.01; r=0.633) genes is indicative of their role in the development of generalised periodontitis in young smokers. For the first time, a protocol for the personalised control of periodontal status in young people has been developed based on the biochemical and molecular genetic profile. This allows for the identification of pre-disease states and the control of the dynamics of the clinical course of chronic catarrhal gingivitis and generalised periodontitis with timely preventive and therapeutic measures.

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