Search academic texts

Information × Registration Number 0117U004053, ( 0223U003347  ) R & D request Title The role of microRNA in metabolic cytoprotection under hypoxia and age-associated diseases Head Portnichenko Alla G, Доктор медичних наук Registration Date 20-01-2017 Organization International Center for Astronomical and Medical-Ecological Research under the Presidium of the National Academy of Sciences of Ukraine popup.description1 Describe the interrelation between the induction of microRNA, metabolic regulatory proteins and cellular response parameters under the influence of different modes of hypoxia, to develop approaches to create methods of treatment of age-related diseases. Implementation of the project involves priority studies of microRNA-dependent mechanisms of regulation of metabolism of experimental animals and humans, as well as the development of protection against metabolic disorders associated with age, under the influence of different modes of alpine hypoxia. Experimental studies will be conducted at the molecular, cellular and subcellular levels in the myocardium, lungs and whole body, it is planned to conduct population studies in volunteers - residents of the plains and midlands. The sequence of induction of growth factors, metabolic proteins, microRNA, activation of signaling pathways and their intercommunication with the development of metabolic cytoprotection under the action of different modes of alpine hypoxia. During the project implementation, it is planned to modernize experimental-clinical laboratories to perform the necessary stages of physiological and molecular-biological research are based on ICAMER in Elbrus, development of experimental models, protocols and recommendations. popup.nrat_date 2024-12-10 Close