Search academic texts

Information × Registration Number 0120U103099, ( 0221U101949  0222U000651  ) R & D request Title Translation elongation factor eEF1A as a new antigen in the formation of autoimmune antibodies in type 1 diabetes and other autoimmune diseases. Head Negrutskyii Borys S., Доктор біологічних наук Registration Date 26-06-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 Autoantibodies that recognize translation elongation factor 1 (eEF1A) have recently been found in the serum of Korean patients with type 1 diabetes (T1D). These antibodies were proposed as a new marker of this disease (Koo et al., 2014), but the specific isoform eEF1A, which acts as an antigen in this case, and the corresponding antigenic determinants remained unknown. Autoantibodies against eEF1A were previously detected in some cases of such infrequent autoimmune diseases as dermatomyositis, Felty syndrome and the effects of Q fever (Mooney et al., 2006, Camacho et al., 2005, Ditzel et al., 2000). Studies on the presence of anti-eEF1A autoantibodies in patients with more common autoimmune diseases, in particular rheumatoid arthritis, have not been conducted. The role of autoantibodies against eEF1A in the development of autoimmune diseases is still unclear. We suggest that destabilization of eEF1A by autoantibodies may inhibit or completely eliminate the known chaperone-like activity of this protein, which in turn can lead to conformational defects in some proteins and, eventually, to the activation of an increased number of autoreactive lymphocytes. Proving such a course of events in the future could be a significant contribution to the theory of induction of T1D, and possibly some other autoimmune diseases. On the practical side, the presence of anti-eEF1A autoantibodies in the serum of patients may become one of the markers for detecting and, possibly, predicting the severity of certain autoimmune diseases. Unfortunately, there is still practically no knowledge about the molecular characteristics of eEF1A and individual isoforms of this protein as autoantigens and information about the presence of auto anti-eEF1A antibodies in case of common autoimmune diseases other than DT1. The aim of this project is to obtain the molecular characteristics of the eEF1A protein and, in particular, its isoforms as antigens in DT1, as well as to determine the possibility of the popup.nrat_date 2024-12-10 Close