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Information × Registration Number 0120U104008, ( 0221U101899  0221U106063  0221U106639  0224U001257  ) R & D request Title Development of continuous-flow approach of safe and scalable utilization of non-stabilized diazoalkanes as reagents for organic synthesis Head Volochnyuk Dmytro M., Доктор хімічних наук Registration Date 25-09-2020 Organization Institute of Organic Chemistry NAS of Ukraine popup.description1 1. To develop safe and efficient semi-industrial protocols for generation and synthetic application of non-stabilized diazoalkanes by a flow approach in multigram scales. 2. To design and assemble an in-house-made flow-through photochemical device suitable for investigations and developments of flow chemical approaches with unstable, hazardous chemicals for industrial needs. 3. To formulate based on kinetic and computational chemistry studies, the substrate-based guidelines for the scope and limitations and capabilities of the developed flow procedures and redicting the reaction behavior during scaling. 4. To improve the modern mechanistic understanding of the diazoalkanes reaction pathways through the analysis of the obtained kinetic results and DFT-modeling outcomes. popup.nrat_date 2024-12-10 Close