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Information × Registration Number 0120U104850, ( 0220U104802  0221U106422  0222U001144  0224U000385  ) R & D request Title Development of combined therapy for severe Klebsiella pneumoniae-associated nosocomial infections to overcome the antibiotic resistance Head Moshynets Olena V., к.б.н. Registration Date 12-11-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 The aim of the project is to develop a new treatment protocol for overcoming multiple resistance to antibiotics, in particular to β-lactams, in the leading causative agent of nosocomial infections with high mortality - multidrug-resistant strains of Klebsiella pneumoniae. For this, new activity of well known macrolide antibiotic azithromycin as an anti-biofilm agent in a combined antibacterial therapy will be studied. Specifically, an effectiveness of azithromycin in a combination with the antibiotic of last reserve but low effectiveness colistin to combat antibiotic resistance in MDR K.pneumoniae will be investigated. One more aim is to investigate whether azithromycin can increase a phenotypic sensitivity to β-lactam antibiotics. Pharmacological mitigation of β-lactam resistance in MDR K.pneumoniae would allow a development and implementation of the first national recommendations in treatment of K.pneumoniae infections. popup.nrat_date 2024-12-10 Close