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Information × Registration Number 0120U104882, ( 0221U101021  0222U001057  ) R & D request Title Creation of new effective inhibitors of Zring formation in order to obtain anti-tuberculosis drugs with antimitotic action Head Karpov Pavlo A., Доктор біологічних наук Registration Date 13-11-2020 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description1 The main goal of the project is the search of fundamentally new inhibitors of the cellular division mechanism of TB pathogens, focused on new, unique molecular targets of the mitotic apparatus of mycobacteria and capable to cause lethal conformational changes of target proteins. This screening involves a harmonious combination of experimental and computational methods, namely: chemical synthesis and creation of a chemical library of compounds, structural and biological study of molecular complexes of the Z-ring apparatus and determination of optimal molecular targets (FtsZ, associated with regulation of Z-ring protein kinase and phosphatase etc.), computer modeling and virtual screening of ligand libraries, spectrophotometric confirmation of interaction and testing of leader compounds using live cultures. popup.nrat_date 2024-12-10 Close