Search academic texts

Information × Registration Number 0120U104978, ( 0220U104584  0221U106656  ) R & D request Title Design and synthesis of new electron-deficient azoles active against viruses causing opportunistic infections Head Brovarets Volodymyr S., д.х.н. Registration Date 19-11-2020 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description1 The aim of the project is the design and synthesis of new bioactive heterocyclic compounds active against viruses that cause opportunistic infections. Preparative methods for the synthesis of electron-deficient azoles with pharmacophore groups will be proposed, their modeling in silico and in vitro testing will be performed, and the relationship between structure and activity will be studied. This will make it possible to find promising compounds on the basis of which new drugs can be created. Synthesis of 4,5-disulfonyl substituted imidazoles and imidazoles with C4 linked to triphenylphosphonium center, and the prediction and study of their biological properties popup.nrat_date 2024-12-10 Close