Search academic texts

Information × Registration Number 0121U109327, ( 0221U106621  ) R & D request Title Synthesis of new derivatives of getaryl chalcones and trifluoromethyl-pyrroles and evaluation of their activity as inhibitors of therapeutically important enzymes Head Sorochynskyi Oleksandr Ye., к.х.н. Registration Date 05-03-2021 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description1 Development of original ways of organic synthesis of trifluoromethyl derivatives of bicyclic azaheterocycles. A detailed study of the catalytic hydrogenation of bicyclic trifluoromethylpyrroles to obtain trifluoromethylated derivatives of pyrrolizidine and indolizidine with a certain stereochemistry is envisaged. Using computer simulation methods and research in model systems, trifluoromethyl derivatives of bicyclic azaheterocycles and getaryl chalcones will be evaluated as inhibitors of therapeutically important enzymes such as glutathione S transferase, protein tyrosine phosphatase and cholinesterase. popup.nrat_date 2024-12-09 Close