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Information × Registration Number 0121U111086, R & D request Title Establishing of molecular processes involved in development of preclampsia via integration of transriptome, proteome and metabolome data of the human placenta Head Obolenska Mariia Yu., Registration Date 20-05-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 The aim of the project is to get insights on etiology and pathogenesis of preeclampsia a systemic approarch of investigating the disease as opposed to studying any particular characteristics (reductionist approach). To this end we will apply modern high throughput methods of molecular biology to perform a bioinformatics analysis of transcriptome, proteome and metabolome in human placenta from the firs, second and third trimesters of pregnanacy in norm, under conditions of preeclampsia and also in smoking affected placenta which is shown to be half as likely suffering from the symptoms of preeclampsia. Openly available high throughput data will be involved with: microarray data and RNA-seq for transcriptome, protein masspectromerty data for proteome and masspectrometry and nuclear magnetic resonance for metabolome. The uniqueness of this study lies in an idea of intra- and cross-omics raw data integration. popup.nrat_date 2024-12-09 Close