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Information × Registration Number 0121U111202, ( 0221U106700  ) R & D request Title Features of interaction of nanoparticles with viruses and microorganisms of different types. Implementation to antiviral and antimicrobial therapy Head Lozovskyi Valerii Z., Доктор фізико-математичних наук Registration Date 28-05-2021 Organization Taras Shevchenko National University of Kyiv popup.description1 Conduct a systematic study of the effects of non-functionalized nanoparticles on viruses, bacteria and fungal microorganisms in order to identify similarities / differences in the mechanisms of action of nanoparticles on pathogens of different types. It is assumed that this mechanism is based on the physical (near-field) interaction between nanoparticles and biological objects, which should be characterized by resistance to the processes of adaptation of pathogens to existing drugs. To do this, it is planned to synthesize nanoparticle preparations that will be different in size, shape, material, structure and stabilizer and experimentally determine the effect of each of these parameters on the infectious activity of pathogens. The results of the experiments will confirm or refute the hypothesis that the near-field interaction of nanoparticles with bioobjects underlies their inhibitory action. Combining experimental results with their theoretical substantiation on the basis of constructed models and conducted simulations will allow to understand details of the mechanism of this interaction, to predict its new features and to estimate prospects of application of the studied mechanism for prevention or treatment of infectious diseases, creation of disinfectants. popup.nrat_date 2024-12-09 Close