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Information × Registration Number 0121U113616, R & D request Title Improving the management of hypertrophic scars taking into account the identification of clinical-instrumental and immunohistochemical subtypes of pathologically altered tissues Head Bisiuk Yurii A., Litus Oleksandr I., Доктор медичних наук Registration Date 29-10-2021 Organization Shupyk National Healthcare University of Ukraine popup.description1 Improve diagnosis and treatment of hypertrophic scars of the skin by identifying clinical criteria, parameters of ultrasound examination of fibrosely changed tissues, concentration of cytokines in peripheral blood (interleukin-10 (IL-10), transforming growth factor-β (TGF-β), plasminogen activator inhibitor type-1 (PAL-1)), This allows us to identify the risk group for the formation of pathological scarring, as well as detect the phenotypic signs of scarring by immunohistochemical examination with the detection of (membrane protein, molecule of intracellular adhesion -CD34, α-smooth muscle actin (α-SMA), protein - p16) for selection of further therapy tactics. popup.nrat_date 2024-12-09 Close