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Information × Registration Number 0122U000770, ( 0223U003213  0224U031362  0225U000889  ) R & D request Title Determination of osteoconductive and osteoinductive properties of polymer-hydroxyapatite biodegradable scaffolds Head Oleshko Oleksandr M., Кандидат медичних наук Registration Date 31-01-2022 Organization Sumy State University popup.description1 The aim of the project is to establish general laws of the creation of three-dimensional polymer hydroxyapatite scaffolds in order to control resorption processes in biological conditions and biocompatibility of implants modified in composition and structure, as well as their antibacterial properties due to the inclusion of silver and zinc oxide nanoparticles. Objectives of the study: 1. Development of optimal concentrations of HA and PCL / PLA ratios, as well as a selection of modes (temperature, metric parameters of pores, and printing fibers) of 3D-print to create three-dimensional polymer-nanohydroxyapatite scaffolds. 2. Creation of three-dimensional polymer-nanohydroxyapatite scaffolds with the addition of different concentrations and shapes of silver and zinc oxide nanoparticles. 3. Determination of physicochemical, corrosion, structural and optical characteristics of the surface of implants obtained by different methods. 4. Determination of the degree of adhesion, proliferation, and metabolism of cells during cultivation on implants with a functionalized surface. 5. Generalization of research results in terms of the possibility of creating biodegradable orthopedic implants popup.nrat_date 2024-12-09 Close