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Information × Registration Number 0122U002126, ( 0223U002320  0224U000619  ) R & D request Title Role of TRP channels in visceral nociception and impaired smooth muscle contractility evoked by general anesthetics Head Galaidych Oleg V., Кандидат біологічних наук Registration Date 23-03-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The goals of this project are to elucidate the significance of TRP channels in visceral nociception and to establish the effects of general anesthetics on TRP channels controlling the vascular tone of pulmonary arteries and cholinergic excitation-contraction coupling in the gut. Balanced general anesthesia is the most commonly used strategy, providing the combination of low-dosage medications to increase the desired effects and reducing the side effects [18]. Thus, we aim to study the effects of various anesthetics (namely propofol, etomidate, fentanyl, dexmedetomidine, lidocaine, acetaminophen) on TRPC4 channels in the gut, and TRPV4 and TRPM8 in the vasculature. popup.nrat_date 2024-12-09 Close