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Information × Registration Number 0122U201744, ( 0223U003774  ) R & D request Title Unprecedented rearrangements of oxazaheterocycles as a new method of synthesis of xanthene dyes for biovisualization Head Farat Oleh K., Доктор хімічних наук Registration Date 22-12-2022 Organization Farat Oleh K. popup.description1 The aim of the work is the synthesis and research of compounds absorbing/emitting in the range of 650-800 nm. Provided the positive results of biochemical tests are obtained, the synthesized compounds can be offered as photostable, low-toxicity, inexpensive fluorescent probes for laboratory experiments of oncological analyses. New methods of targeted synthesis of fluorescent and pharmacophore materials will be developed. The regularities of the influence of the chemical modification of the xanthene fragment, substituents and various solvents on the spectral properties will be established. Important parameters for tumor markers and optical filters will be determined, such as the stability of the binding complexes of fluorescent dyes with cell molecules, photo- and chemical stability in the solution with changes in pH and temperature of the environment, establishing safety for unaffected cells. It is expected that the synthesized fluorophores will combine photo- and chemical stability under pH and temperature changes with low toxicity, and will be capable of modulating their fluorescence. popup.nrat_date 2024-12-09 Close