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Information × Registration Number 0123U100755, ( 0226U001450  ) R & D request Title To study the dose-dependent features of modeling hypometabolism and hypothermia in a hypoxic-hypercapnic environment and to develop the technology of its application for the rehabilitation of war victims Head Muradyan Khachik K., Доктор біологічних наук Registration Date 01-02-2023 Organization D. F. Chebotarev Institute of Gerontology of the National academy of the medical sciences of Ukraine popup.description1 The inverse relationship between the rates of metabolic processes and aging is one of the fundamental laws of gerontology. That is why the controlled decrease in the intensity of metabolism and body temperature with the help of a hypoxic-hypercapnic environment (HGS) is an evolutionarily consistent mechanism for reducing the frequency of age-related pathology and prolonging life. An important and still unsolved problem remains the selection of such conditions of HGS, which would ensure the maximum decrease in the intensity of metabolic processes with minimal trauma to the experimental animals. A successful solution to this problem would open perspectives for the recommendation of the studied model of hypometabolism for subsequent clinical trials. Along with previously tested "hard" models of HGS, which showed high efficiency of their application on laboratory animals, it is planned to study the possibility of creating more "soft" models of hypometabolism and hypothermia. popup.nrat_date 2024-12-09 Close