Search academic texts

Information × Registration Number 0123U100998, R & D request Title Specific G-quadruplex ligands as inductors of DNA damage Head Dubei Ihor Ya., Доктор хімічних наук Registration Date 10-02-2023 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 The aim of the project is a development of efficient G-quadruplex (G4) ligands able to exhibit antitumor activity via the induction of DNA damage, investigation of their interactions with quadruplexes of various topologies by biochemical and biophysical methods and computer modeling, and study of biological activity of new compounds in tumor cell cultures, including the effects of simultaneous use of G4 ligands and DNA repair inhibitors popup.nrat_date 2024-12-09 Close