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Information × Registration Number 0123U101863, ( 0223U005369  ) R & D request Title Prediction of bioactivity and creation of modern approaches to the synthesis of heterocyclic compounds for the needs of the pharmaceutical industry. Chapter 2. Development of new QSAR models for activity prediction and synthesis of new chemical compounds of heterocyclic nature as antimicrobial, antiviral and anticancer agents Head Brovarets Volodymyr S., д.х.н. Registration Date 24-03-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description1 Development of effective methodologies for the construction of functionalized heterocyclic systems and molecular platforms for the creation of new active ingredients for the pharmaceutical industry: five- and six-membered nitrogenous heterocycles and their condensed derivatives. Study of transformations of condensed heterocyclic systems, which contain structural fragments effective for further pharmacophore modification. Development of new original methods of functionalization of small and medium heterocyclic nuclei. Computer design of new target-oriented biologically active compounds of heterocyclic nature with a selective type of biological action. Experimental studies of compounds of heterocyclic nature with predicted high antimicrobial, antiviral and anticancer activity. Assessment of ecotoxicological risks of exposure to newly synthesized compounds of heterocyclic nature with the involvement of the hydrobiont Daphnia magna as a biomarker. popup.nrat_date 2024-12-09 Close