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Information × Registration Number 0123U102561, ( 0224U032212  ) R & D request Title Experimental and pharmacological approaches to the study of pathological conditions of the body Head Veselovskyi Mykola S., Доктор біологічних наук Registration Date 16-05-2023 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 Investigation of the effect of metal ions with different valences on high-conductivity cation channels of the nuclear membrane of Purkinje neurons of the cerebellum. Investigation of the peculiarity of the action of cerium dioxide nanoparticles on the damaging effect of beta-amyloid on hippocampal neurons in culture in the simulation of Alzheimer's disease. Identification of new molecular determinants involved in the mechanism of activation of bladder smooth muscle contraction (detrusor) by agonists of muscarinic acetylcholine receptors. Study of structural and functional changes of the sciatic nerve of transgenic mice with peripheral neuropathy and study of the impact of MMSC transplantation on the functional state and ultrastructural features of the sciatic nerve in this pathology. The aim of the study is to study the effects of pharmacological stimulation of the synthesis of endogenous hydrogen sulfide on the functional state of the respiratory chain of the mitochondria of the heart of rats of different ages. Investigation of the effects of nociceptive-proprioceptive signaling from tired skeletal muscles on the electrical activity of the cerebral cortex of anesthetized rats during changes in the concentration of Ca2 + in muscle tissue caused by the introduction of activator or calcium channel blocker. To establish the mechanisms of influence of phosphatidylcholine liposomes on the reprogramming of alveolar macrophages and the anti-inflammatory effect mediated by them in experimental pneumonia. Study of modulation of the state in which actin is located, by ions of metals and nucleotides, on the formation of apoptosomes in the cytoplasm of neurons and glia. popup.nrat_date 2024-12-09 Close