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Information × Registration Number 0123U102648, ( 0223U005308  ) R & D request Title Structurally modified natural compounds of the bromotyrosine series as inhibitors of bacterial biofilms for the prevention and treatment of persistent infections Head Smolii Oleh B., д.х.н. Registration Date 24-05-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description1 The research aims to synthesize structurally modified bromotyrosine derivatives of natural origin in order to develop the promising inhibitors of bacterial biofilms, to study the antimicrobial activity of the obtained compounds against biofilm microorganisms and to clarify certain aspects of the inhibitory mechanism. The project will focus on the development of effective methods for modifying bromotyrosine analogs with various pharmacophore groups and fragments of known drugs, as well as researching antibacterial and antibiofilm activity against gram-positive and gram-negative bacteria. popup.nrat_date 2024-12-09 Close