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Information × Registration Number 0123U102849, ( 0223U004655  0224U032603  0225U004253  ) R & D request Title Molecular design, synthesis and screening of new potential antiviral pharmaceutical ingredients for the treatment of infectious diseases COVID-19 Head Kyrychenko Oleksandr V., Доктор хімічних наук Registration Date 09-06-2023 Organization Karazin University popup.description1 The project aims to develop pharmacophore, molecular-dynamic models, generate de novo chemical space according to the DAECS algorithm, and carry out screening for new inhibitors of SARS-CoV-2 virus proteases. Based on the mechanisms of specific binding of Mpro and PLpro proteases to ligands, design dual-acting inhibitors that are promising for developing anticoronavirus drugs and synthesize hit-molecules taking into account ADMET parameters, and, finally, determine their activity in vitro. popup.nrat_date 2024-12-09 Close