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Registration Number

0123U102859, ( 0223U004702  0224U032660  0225U004272  ) R & D request

Title

Development of an enzyme kit and a portable biosensor for express assay of creatinine – a marker of acute renal dysfunction

Head

Honchar Mykhailo V., д.б.н.

Registration Date

12-06-2023

Organization

Institute of Cell Biology of the National Academy of Sciences of Ukraine

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The aim of the project is the synthesis, study of structural, physicochemical and catalytic properties of new catalytically active nanomaterials, namely, artificial enzymes (nanozymes); creation on their basis of new diagnostic methods and study of biological action of nanocomposites on eukaryotic cells (in particular, yeast). The creation of new nanomaterials with catalytic properties will allow the development of new methods of highly sensitive quantitative detection of a number of practically important substances (glucose, lactic acid, alcohols) for clinical diagnosis, sports medicine and food technology. The relevance of the planned research is related to the need in development of selective, sensitive and at the same time inexpensive methods for analysis of practically important analytes - biomarkers of the most common diseases or indicators of food quality. Socioeconomic significance of the planned work is the need to replace natural enzymes with inexpensive artificial catalysts in bio/chemosensors and analytical kits, as well as improving the sensitivity, assay time and cost of sensor systems by including nanoparticles with catalytic activity (nanozymes) in the recognition layer.

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2024-12-09