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Information × Registration Number 0123U104160, R & D request Title Dual targeting of tumor-specific vulnerabilities by novel thiosemicarbazone derivatives Head Stoika Rostyslav S., д.б.н. Registration Date 10-10-2023 Organization Institute of Cell Biology of the National Academy of Sciences of Ukraine popup.description1 The project is aimed at the development of novel effective approaches for cancer treatment by targeting two main tumor-specific vulnerabilities - abnormally high expression of mutant p53 protein and immunological tolerance to cancer. In order to reach these goals, novel thiosemicarbazone derivatives - COTI-2, COTI-NMe2 and KP1550, which are characterized by a unique dual action towards malignant cells, will be addressed here. popup.nrat_date 2024-12-09 Close