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0124U001684,
(
0225U005069
)
Redox-dependent mechanisms of changes in cardiovascular function in aging and doxorubicin-induced heart failure.
Sagach Vadym F., д.мед.н.
13-02-2024
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
The aim of this study is to investigate redox-dependent mechanisms of changes in cardiovascular function in aging and doxorubicin(DOX)-induced heart failure. Particular attention will be paid to DOX-induced mitochondrial dysfunction in the rat heart and the role of ATP-sensitive potassium channels (KATP channels) as well as endogenous antioxidants - glutathione and gas transmitters. It is known that KATP channels are universal regulators of cellular functions and metabolism, which determines their key role in defense mechanisms. The work will investigate the functioning of the cardiovascular system in experimental DOX-induced heart failure (cardiotoxicity) in rats and in conditions of activation of endogenous defense mechanisms. Also, the search for antioxidant agents for the correction of cardiac disorders of different genesis (aging, DOX-induced heart failure) will be carried out, in particular the effect of KATP channel openers and new nanomaterials as potential antioxidants, etc. The role of melatonin deficiency (hypomelatoninemia) in the development of cardiac mitochondrial dysfunction will be established and the functional state of the cardiovascular system under conditions of inhibition of endogenous melatonin synthesis will be studied.
2024-12-09
Updated: 2025-12-26
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