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Information × Registration Number 0125U002516, R & D request Title To establish criteria for prognostic assessment of cognitive functions based on human walking parameters, to set the features of transplanted mesenchymal stromal cells influence on brain structures in acute ischemia-reperfusion experimentally, to give histochemical characteristics and clarify the features of hypothalamic neurons activation during alcohol intoxication Head Yoltukhivskyi Mykhailo V., д.мед.н. Registration Date 15-05-2025 Organization Vinnytsia National Pirogov Memorial Medical University popup.description1 1. To establish criteria for prognostic assessment of cognitive functions based on human walking parameters. The purpose: to establish age and gender characteristics of changes in spatial-temporal walking parameters when performing additional cognitive tasks in practically healthy people and people of both genders with different ages having walking disorders. To determine the following parameters of human walking: walking speed, number of steps when walking on a track, number of steps per minute, step length, double step length, ratio of step length to length of a lower limb, width of support base, step time, step cycle time, foot transfer time, support time, support time on both feet, structure of a step cycle, integral indicator of “normal walking| quality – FAP. To analyse the listed indicators of spatial and temporal walking parameters in real time under physiological paradigms, in particular walking with additional cognitive tasks. Based on the obtained indicators of spatial and temporal walking parameters in real time, establish a specific prognostic significance of walking parameters estimates to improve the quality of diagnostics, solving expert questions. 2. Features of the transplanted mesenchymal stromal cells influence on brain structures in acute ischemia-reperfusion. The purpose of the study is to perform a comparative analysis of the effectiveness in transplantation of hWJ-MSCs, their exosomes and cryopreservative from them, and to evaluate the cerebroprotective actions on the hippocampus in acute cerebral IR with the justification of the feasibility of a new drug creating, based on the most promising of them. 3. To give histochemical characteristics and clarify the features of the hypothalamic neurons’ activation in alcohol intoxication. The purpose is to establish the features of the immunohistochemical and histochemical activity of neurons in different hypothalamic nuclei in acute alcohol intoxication and addiction formation in rats. popup.nrat_date 2025-05-15 Close