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Information × Registration Number 0125U002578, R & D request Title Total Neoadjuvant Chemotherapy With 5-fluoruracil, Leucovorin, Oxaliplatin and Docetaxel in Locally Advanced Gastric and Gastroesophageal Junction Cancer (OCTASUR): Randomized, Single Center, Open Label Trial, Phase 2/3 Head Kondratskyi Yurii M., Registration Date 27-05-2025 Organization National Cancer Institute popup.description1 Perioperative FLOT chemotherapy is a golden standard of care for stage II and III of gastric cancer. IVA stage may undergo surgical curative resection when downstaging with neoadjuvant chemotherapy is achieved. However, after surgery patients are often not fit enough to successfully complete 4 adjuvant cycles of this scheme. The main reason for this study is the lack of any randomized clinical trials on determining the effectiveness of total neoadjuvant chemotherapy (TNT) and studies of the TNT impact on overall survival (OS) and progression-free survival (PFS) in the world popup.nrat_date 2025-05-27 Close