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Information × Registration Number 0125U002946, R & D request Title Study of antiviral and antitumor activity of natural oligoribonucleotide degradation products and their mechanism of action Head Tkachuk Zenovii Yu., к.б.н. Registration Date 10-07-2025 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 Search for potential antiviral and antitumor drugs based on protonated nucleotides (PNs), which will have a virucidal effect by inhibiting the critical stages of viral protein entry into the cell, which are involved in the processes of viral infection, and also will have antitumor activity.It is expected to establish the mechanism of action of PNs, screening of the most active drugs on critical proteins of viruses, on experimental antiviral models in vitro, as well as on models of suspension cultures of tumor cells and on models of leukemia in vitro;identifying the ability of the most active PNs to regulate the innate immune response to virus infection and tumor processes in animals in vivo, and screening the anti-inflammatory effect of PNs in model systems, as well as studying the antithrombotic effect of PNs in model systems in vitro; study of PNs for the prevention and treatment of ARVI infection and leukemias in vivo. popup.nrat_date 2025-07-10 Close