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Information × Registration Number 0125U003233, R & D request Title Analysis and characterization of subvisible particles from elastomeric closure components by Raman microspectrometry Head Prykhodko Roman V., Доктор хімічних наук Registration Date 04-09-2025 Organization National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute» popup.description1 Particle identification and quantification of sub-visible particles play a key role in the pharmaceutical industry, particularly in regulatory monitoring and contamination source determination. Depending on the product matrix, the selection of an appropriate isolation and preparation method is crucial to preserve the integrity of the unknown particles. Once isolated, the choice of instrumental analysis is essential to determine their identity. Solid-state analytical techniques such as optical microscopy, molecular microspectrometry, Raman spectroscopy, and even mass spectrometry can be used to obtain valuable chemical information. In this work, optimal detection and analysis methods were established to assess submicron particle loading from elastomeric closure components. popup.nrat_date 2025-09-04 Close