Search academic texts

Information × Registration Number 0200U001157, 0197U001112 , R & D reports Title To investage properties of caunterreceptor factors to insulin and testosteron receptops popup.stage_title Head Korpachev V.V., Registration Date 08-12-2000 Organization V.P.Komisarenko Institute of Endoсrinology and Metabolism popup.description2 Objective: The blood serum factors (proteins) which can modulate processes of interaction between insulin and testosteron and their receptors in patients with non-insulindependent diabetes mellitus (NIDDM) were investigated. Methods: biochemical, immunochemical; clinical observation, animal experiment. Results. The original method of preparative isolation of an electrophoretically homogeneous fraction of insulin receptor binding protein (МW 150 kDa) from human blood serum was developed. The fraction of insulin binding protein with high affinity to insulin (MW 35 kDa) was revealed in blood serum. It was shown that the both proteins are not anti-insulin antibodies and are able to cause a diabetes-like status after the single injection to rats. The increased level of antibodies to some membrane phospholipids in blood serum of 120 patients with both type 1, and type 2 diabetes was revealed. The opportunity of shielding of membrane insulin receptors by these antibodies is supposed. The significan ce correlation between serum levels of testosteronestradiolbinding globulin (TEBG), insulin and testosteron levels is revealed, depending on a degree of the carbohydrate and lipid metabolism impairment at the men and women with diabetes. The data suppose a specific diagnostic significance of a TEBG level as parameter of androgenic status and insulin resistance marker at the NIDDM patients. Product Description popup.authors popup.nrat_date 2020-04-03 Close