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Information × Registration Number 0200U001677, 0197U006499 , R & D reports Title Study of significance of surface structure expression on tumor cells for its interaction with lymphocytes in different tumor growth stages popup.stage_title Head Berezhnaya N.M., Registration Date 15-03-2000 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was shown that lymphocyte antitumor activity of mouse with different tumor growth models had considerable distinctions not only in growth dynamic, but in comparison of this models. Under MH-transplanted tumor growth lymphocyte antitumor activity combined with CD25 high level expression on lymphocytes and IgM and CD54 on tumor cells; under MH-cancerogenesis - with marker of proliferation on lymphocytes; under melanoma B16 - with CD54 exrpession on lymphocytes and marker of proliferation on tumor cells. The breach of regulation in the IL-2 and TGF-b levels have the major role in devolopment of B-lymphocyte hyperreactivity. Lymphocytes (B-subpopulation and common pool ) of patients with atopic allergic diseases have antitumor activity; this activity enhanced under the addition of autologous serum from patients to the interaction of tumor cells and lymphocytes Product Description popup.authors popup.nrat_date 2020-04-03 Close