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Information × Registration Number 0200U001683, 0195U005360 , R & D reports Title Study on molecular mechanisms of specific recognition and aminoacylation of tRNA by a second class aminoacyl-tRNA synthetases. popup.stage_title Head Tukalo M.A., Registration Date 16-03-2000 Organization Institute of molecular biology & genetics popup.description2 Structures of 4 second class aaRS and 6 tRNA from T.thermophilus have been studied. Role of Mg for aminoacide activation and support U-conformation of ATP in enzyme site has been shown. Two-step mechanism of tRNA recognition by second class aaRS is proposed. At the first step enzyme recognizes specific 3D structure of tRNA: - SerRS recognizes a long variable loop and LyzRS and ProRS recognizes anticodones. A recognition is completed after aminoacyl-adenilate formation. Branch: molecular biology. Product Description popup.authors popup.nrat_date 2020-04-03 Close