Search academic texts

Information × Registration Number 0200U001709, 0197U004658 , R & D reports Title Investigation of the role of polypeptide growth factors in normal and tumor cells response to action of stress agents. popup.stage_title Head Stojka R.S., Registration Date 15-03-2000 Organization Division of Regulatory Cell Systems Institute of Biochemistry popup.description2 It was found that stress agents stimulate TGF-(1 production by L1210 and A-549 cells and inhibit TGF-( expression. TGF-(1 induced decreasing of sensitivity to the hyperthermia effects in A-549 cells. Cisplatin-resistant cells L1210 produce more TGF-(1 and are concomitantly resistant to TGF-( growth-inhibitory effect while more sensitive to heat shock and mistletoe lectines. Obtained results suggest different response of cells to action of stress agents including resistance to them. Final TGF-(1 bioeffect defined by cellular competence and putative mechanism for realization of cytokine action. Product Description popup.authors popup.nrat_date 2020-04-03 Close