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Information × Registration Number 0200U003733, 0197U008964 , R & D reports Title Specifisity of interaction of drugs with DNA. Determination of the nature of physical-chemical factors wich are responcible for selectivity of binding of drugs having different biological activity with the definit DNA sequences popup.stage_title Head Veselkov O. N., Registration Date 07-09-2000 Organization Sevastopol State Technical University popup.description2 1H-1H and 1H-31P correlation NMR spectroscopy have been used to investigate the proces of formation of hairpin and duplexes of self-comlementary and nonself-complementary deoxy- (octa-, hepta-, hexa- and tetra) -nucleotides and their complexes with ethidium bromide and daunomycin in aqueous solution. The equilibrium constants and thermodynamic parameters of complexation. Structures of the molecular complexes have been build. The conclusions about sequence-specificity of intercalative binding of aromatic ligands with the deoxyoligonucleotides and about the intermolecular forces stabilising complexes in solution have been made. The obtained results may be used in the field of biophysics, molecular and medical physics, pharmacology. Product Description popup.authors popup.nrat_date 2020-04-03 Close