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Information × Registration Number 0200U004884, 0198U007052 , R & D reports Title Finding - out of mechanisms of activity of a brain at Alzheimer's disease, vascular and senile dementies as theoretical basis for their differential diagnostics. popup.stage_title Head Kazakov Valerij Mykolajovych, Registration Date 14-12-2000 Organization Donetsk state medical University named after M. Gorky popup.description2 Object of research: 25 patients with Alzheimer's disease, 30 patients with a vascular dementia, 30 patients with senile dementia, 30 men - monitoring group (mentally healthy people in the age from 60 till 65 years). The purpose of activity: To find out electrophysiological, biochemical, morphological changes in activity of a central nervous system, and also immunological and genetic features of an organism of the patients with different kinds of a dementia. Method of testings: cognitive evoked potentials of a brain, EEG mapping, computed tomography, cytogenetic research, the immunological researches were conducted through following techniques: the quantitative determination T - and B - lymphocytes, quantity of serumal immunoglobulins was determined by a method of a radial immunodiffusion, the sensibilization of lymphocytes to cerebral antigen was investigated in drag reaction of migration of leucocytes, at biochemical researches determined a malonic dialdehyde, diene conjugates, activity SOD, catala se. Received outcomes: the particular tokens of Alzheimer's disease are detected: indexs of the immune status, condition oxidative and antioxidative systems, chromosome and genome aberration, topographic and spectral distribution law of electrical activity of a brain. Novelty: the new fundamental data reflecting gears of activity of a brain are received at a physiological mental aging and Alzheimer's disease. The invention " A way of early diagnostic of dementias of late age " is sent to the application. Product Description popup.authors popup.nrat_date 2020-04-03 Close