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Information × Registration Number 0201U003372, 0198U005183 , R & D reports Title Development of methods to enhance effectiveness of alkylating antitumor drugs by inactivation of repair protein O6-alkylguanine--DNA alkyltransferase. popup.stage_title Head Mykhajlenko Viktor Mykhajlovych, Registration Date 21-02-2001 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 As a result of execution of work the inhibitor is synthesized AGT-O6-benzylguanine (BG) , the model system is built and is investigated dynamics(changes) of change of activity AGT and accumulation of adducts in DNA, the optimum regime of introduction BG and alkilating drug is defined, the dissolvent and dose for BG, other picks up. Is exhibited, that usage BG sinks activity AGT on 90-99 of %, that allows to raise(increase) sensitivity of a tumour to a drug and to sink a dose last in 8 times. The design of the methodical guidelines on usage of a method of intensifying of therapeutic efficacy alkylating antitumoral drugs and lowering of their toxic operation is prepared. Product Description popup.authors popup.nrat_date 2020-04-02 Close