Search academic texts

Information × Registration Number 0201U003375, 0198U001090 , R & D reports Title Investigation of the drug resistance phenotypic properties transfer process to normal and tumour cells popup.stage_title Head Chekhun V.F., Registration Date 21-02-2001 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 KB, CaOv, A2780 cisplatin and doxorubicin drug resistance human tumour sublines was produced. We produced also mouse lympholeucosis L1210 and rat carcinoma Geuren cisplatin and doxorubicin drug resistance tumour. Primary tumour and tumour lines an its resistance variants was investigated by molecular-biology, biochemical, electronic-microscopy methods. The damage expression of the apoptosis regulatory protein and changed apoptosis signal recovered MKAT had finded. Bcl2, p53, MDR tumour protei s expression increases into the CaOv/Dox and А2780/Dox drug resistance sublines. CD95/Fas antigen superficial expression level more increased in the КВ drug sensitive cell line that have supersensitive to CD95-required apoptosis. On this data the new method of the pharyngeal and laryngeal neoplasms cancer treatment was proposed. I clinical trial phase local using МКАТ IПО-4 to CD95 combinated with cisplatin at the pharyngeal and laryngeal neoplasms cancer patients estimat d more effect than standart treatment. At Product Description popup.authors popup.nrat_date 2020-04-02 Close